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Condition: Diabetes Mellitus

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Prevalence of Diabetes Mellitus in U.S. Youth in 2009: The SEARCH for Diabetes in Youth Study.
ConclusionDiabetes mellitus, one of the leading chronic diseases in childhood, affects over 190,000 (1 out of 433) youth less than age 20 years in the US, with racial and ethnic disparities seen in diabetes prevalence, overall and by diabetes type. PMID: 24041677 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 16, 2013 Category: Endocrinology Authors: Pettitt DJ, Talton J, Dabelea D, Divers J, Imperatore G, Lawrence JM, Liese AD, Linder B, Mayer-Davis EJ, Pihoker C, Saydah SH, Standiford DA, Hamman RF, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities
In conclusion, common comorbidities directly alter pulmonary vascular control, by enhanced PDE5 and endothelin-mediated vasoconstrictor influences, well before overt left ventricular backward failure or pulmonary hypertension develop.
Source: Basic Research in Cardiology - September 12, 2021 Category: Cardiology Source Type: research

Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease
In conclusion, common comorbidities in swine result in CMD, in the absence of appreciable atherosclerosis, which is severe en ough to produce perturbations in myocardial oxygen balance, particularly during exercise, resembling key features of INOCA.
Source: Basic Research in Cardiology - February 24, 2020 Category: Cardiology Source Type: research

Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors
In conclusion, five months of combined exposure to DM + HFD + CKD produces coronary endothelial dysfunction due to impaired NO bioavailability, resulting in impaired myocardial perfusion at rest and during exercise.
Source: Basic Research in Cardiology - August 26, 2021 Category: Cardiology Source Type: research

Transcriptomic analysis of the harvested endothelial cells in a swine model of mechanical thrombectomy
ConclusionECs harvested during MT can be cultured and analyzed using single-cell transcriptomic techniques. This analysis can be implemented in clinical practice to study the EC gene expression of comorbidities, such as hypertension, diabetes mellitus, and metabolic syndrome, in patients suffering from acute ischemic stroke.
Source: Neuroradiology - May 14, 2018 Category: Radiology Source Type: research

Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia
Abstract: Pharmacologically induced angiogenesis could be a promising option in clinical situations with diffuse inoperable coronary artery disease e.g. metabolic syndrome and diabetes mellitus. The failure of focused cytokine, stem cell and gene therapies to achieve both perfusion and functional improvement in clinical trials suggests a more centralized control mechanism. Neuropeptide-Y (NPY) is one such natural neurotransmitter that is known to exert a multifaceted role during neo-angiogenesis and can possibly act as the central control. To date, the ability to harness the ‘master switch’ nature of NPY in a specific ...
Source: Journal of Molecular and Cellular Cardiology - September 13, 2012 Category: Cytology Authors: Robina Matyal, Louis Chu, Feroze Mahmood, Michael P. Robich, Angela Wang, Philip E. Hess, Sajid Shahul, Duane S. Pinto, Kamal Khabbaz, Frank W. Sellke Tags: Original Articles Source Type: research

A GLP-1 Analog Liraglutide Reduces Intimal Hyperplasia After Coronary Stent Implantation via Regulation of Glycemic Variability and NLRP3 Inflammasome/IL-10 Signaling in Diabetic Swine
ConclusionsLiraglutide treatment reduces intimal hyperplasia after stent implantation via regulation of glycemic variability, the NLRP3 inflammasome, and IL-10 in diabetic pigs in a GLP-1 receptor-dependent manner. Reducing the inflammation induced by glycemic variability may be one of the cardioprotective mechanisms of liraglutide.
Source: Frontiers in Pharmacology - March 25, 2020 Category: Drugs & Pharmacology Source Type: research

Translating search strategies (updated)
This is an update of a post from November 2015.If you are doing a systematic review, you will need to run the same search in more than one database.I use the term " translation " for the process of modifying a search so that it works in another database.It is important to run the same search in all databases.So, if you have a search that works in Ovid Medline, what do you need to change to make it work in another database like PsycINFO or Embase?  Those other databases have different features or functionality.There are three areas where translation is necessary, once you have finalised your strategy:Search syntax – ...
Source: Browsing - August 22, 2017 Category: Databases & Libraries Source Type: blogs

Try the new Cochrane PICO search BETA on the Cochrane Library
Cochrane is excited to announce the beta release of a powerful and easy-to-use new discovery tool for finding reviews on theCochrane Library.Released to coincide with the Santiago Cochrane Colloquium, Cochrane PICO search BETA can help you find the most relevant Cochrane evidence to answer your research or clinical question.What is the Cochrane PICO search BETA?With Cochrane PICO search BETA, you can search over 4,500 Cochrane intervention reviews published since 2015 byPopulation (or Patient or Problem)What are the characteristics of the patient or population – for example condition? Intervention What is the interventi...
Source: Cochrane News and Events - October 15, 2019 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Translating search strategies
Not sure if I borrowed this term, or invented it, but I mean modifying a search strategy for use in another database.   For example, if you have a Medline strategy, what do you need to change to make it work in, say, PsycINFO or Embase?  Other databases might have different features or functionality.There are two areas where translation is necessary, once you have finalised your strategy.  I have assumed in what follows that you have a Medline strategy, and want to translate it for use in other databases.One area is search syntax (proximity operators, truncation, and so on), and the other is subject hea...
Source: Browsing - March 22, 2015 Category: Databases & Libraries Tags: literature searching Source Type: blogs

Electromagnetic Interference From Electronic Devices Used in the Management of Type 1 Diabetes Can Impair the Performance of an Avalanche Transceiver in Search Mode
Conclusions Electromagnetic interference produced by some diabetes devices when held within 30 cm of a searching avalanche transceiver can impair the ability to locate a signal. Such interference could significantly compromise the outcome of a companion rescue scenario. Further investigation using other pumps and rtCGMS devices is required to evaluate all available diabetes electronics. Meantime, all electronic diabetes devices including rtCGMS and insulin pumps should not be used within 30 cm of an avalanche transceiver.
Source: Wilderness and Environmental Medicine - March 13, 2015 Category: Environmental Health Source Type: research

The search for predictive metabolic biomarkers for incident T2DM
The search for predictive metabolic biomarkers for incident T2DM, Published online: 18 June 2018; doi:10.1038/s41574-018-0045-xA recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.
Source: Nature Reviews Endocrinology - June 18, 2018 Category: Endocrinology Authors: Ewan Pearson Jerzy Adamski Source Type: research

Transition From Pediatric to Adult Care for Youth Diagnosed With Type 1 Diabetes in Adolescence
CONCLUSIONS: Transferring from pediatric to adult care, experienced by more than half the sample, was associated with an increased risk of poor glycemic control at follow-up. These findings suggest that young adults need additional support when moving to adult care.
Source: PEDIATRICS - April 1, 2013 Category: Pediatrics Authors: Lotstein, D. S., Seid, M., Klingensmith, G., Case, D., Lawrence, J. M., Pihoker, C., Dabelea, D., Mayer-Davis, E. J., Gilliam, L. K., Corathers, S., Imperatore, G., Dolan, L., Anderson, A., Bell, R. A., Waitzfelder, B., for the SEARCH for Diabetes in Yout Tags: Endocrinology Article Source Type: research